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Couture holds a Canada Research Chair in Structural Biology and Epigenetics studying lipid-protein and protein-protein interactions in the context of the structural regulation of transcription. Research Interests Research interests of Carleton Immersive Media Studio include the representation and creation of architecture, religion and architecture, microhistory, hybrid representation, and ethno-cultural materials and methods of construction (architecture, science, engineering, and biomedical imaging/representation). He holds the Diener Chair in Neurodegenerative Diseases and is the Director of the Microscopy Imaging Laboratory in the Centre for Research in Neurodegenerative Disease, University of Toronto.Research Interests Research in the Couture laboratory focuses on cellular epigenetics. Couture uses structural techniques to examine how chromatin (and associated protein) dynamics regulate 1) histone modifying enzymes (HMEs), 2) polypeptide cofactors regulating HME activities and 3) histone deposition. Architectural technologies, and ethno-cultural explorations are applied to the representation of molecular and cognitive changes in diseased brain. Research Interests Research in the Fraser laboratory focuses on the biochemistry and biophysics of amyloid plaques and their relationship to familial and sporadic Alzheimer Disease. She is a Senior Research Scientist at the Sunnybrook Health Sciences Centre and Professor at the University of Toronto.Program Curriculum [details] Neuroscience/Cell Biology; Themes: A, E Dr. Research Interests The Park laboratory focuses on investigating the signaling pathways involved in neuronal cell death. Schlossmacher is a neurologist and Canada Research Chair in Parkinson's Disease exploring the quantification of alpha-synuclein protein and its lipid modifications for biomarker purposes in Parkinson's Disease.Two specific areas are targeted: 1) examining the signaling molecules that control apoptosis via trophic factor deprivation, 2) Identify the relevant apoptotic regulators in animal models of brain pathology. He is a Senior Scientist at the OHRI and holds the Bhargava Research Chair in Neurodegeneration at the Ottawa Hospital. Slack is a neuroscientist studying molecular mechanisms of neurogenesis and neurodegeneration.
Program Curriculum [details] Biomarker/Drug Discovery; Themes: A, C, D Dr. Research Interests Research in the Yao laboratory focuses on the lipid and protein factors that regulate the biosynthesis of low and high density lipoproteins (LDL and HDL) yielding insights into the molecular mechanisms responsible for various diseases, including familial defective apo B (that causes high blood concentration of LDL), familial hypobetalipoproteinemia and familial abetalipoproteinemia (both have abnormally low blood concentration of LDL), and familial combined hyperlipidemia (caused by overproduction of disease-causing lipoproteins).
This type of research is crucial for the development of effective therapies for the treatment of acute brain injury. Research Interests Research in the Tandon laboratory focuses on Parkinsons disease (PD), a progressive neurodegenerative disorder that is influenced by genetic and environmental factors.
Program Curriculum [details] Neuroscience/Cell Biology; Themes: A, C Dr. α-Synuclein (α-syn) is a key pathogenetic factor involved in both inherited and sporadic forms of PD, as well as other neurodegenerative diseases.
Program Curriculum [details] Neuroscience/Cell Biology; Themes: A, C Dr. The goal of the Lanctt laboratory is to optimize the psychopharmacological management of these neuropsychiatric symptoms.
Program Curriculum [details] Biomarker/Drug Discovery; Themes: D, E Dr.
Program Curriculum [details] Neuroscience/Cell Biology; Themes: A-F Dr. Research Interests Research in the Black laboratory focuses on neural degeneration and regeneration with regards to stroke and stroke recovery.